Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
نویسندگان
چکیده
منابع مشابه
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP). β-secretase inhibitors reduce Aβ levels, but mechanism-based side effects arise because they also inhibit β-cleavage of non-amyloid substrates like Neure...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2016
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2016.01.076